Primary hyperparathyroidism uptodate Mar 15, 2023 · Primary hyperparathyroidism is characterized by abnormal regulation of PTH secretion by calcium, resulting in hypersecretion of PTH relative to the serum calcium concentration. Oct 11, 2021 · Parathyroid carcinoma is a rare cause of primary hyperparathyroidism, which is usually caused by a parathyroid adenoma and occasionally by primary parathyroid hyperplasia. An open four-gland parathyroid exploration has traditionally been considered the gold standard for patients undergoing surgery for Diagnostic approach to hypercalcemia, focusing on primary hyperparathyroidism and malignancy as the most common causes, with insights into diagnosis and management. Experimental findings have advanced our understanding of the pathophysiology and causes of primary hyperparathyroidism. Although anemia has not been widely appreciated as a complication of primary hyperparathyroidism, 5. Jul 22, 2025 · The diagnosis of hyperparathyroidism is usually first suspected because of the finding of an elevated serum calcium concentration. (See "Primary hyperparathyroidism: Diagnosis, differential diagnosis, and evaluation". AIM To study the risk of renal stone episodes and risk factors for renal stones in primary hyperparathyroidism before and after The last international guidelines on the evaluation and management of primary hyperparathyroidism (PHPT) were published in 2014. AU Schnatz PF, Curry SL SO Obstet Gynecol Surv. 2000;85 (10):3541. Hyperparathyroidism and hypercalcemia can lead to symptoms such as nephrolithiasis and osteoporosis. Although primary hyperparathyroidism today is often a relatively asymptomatic disease, it has distinct biochemical and skeletal features. CONTEXT Low 25-hydroxyvitamin D levels are common in patients with primary hyperparathyroidism (PHPT) and associated with higher PTH levels and hungry bone syndrome after parathyroidectomy (PTX). metaDescription}} 96 PubMed TI Primary hyperparathyroidism: is there an increased prevalence of renal stone disease? AU Suh JM, Cronan JJ, Monchik JM SO AJR Am J Roentgenol. ) UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women May 24, 2022 · The diagnosis of primary hyperparathyroidism (PHPT) is usually made by finding a PTH concentration that is frankly elevated or within the normal range but inappropriately normal given the patient's hypercalcemia (figure 1). INTRODUCTION Normocalcemic primary hyperparathyroidism (NPHPT) is defined by normal serum calcium and consistently elevated PTH levels after ruling out the causes of secondary hyperparathyroidism. metaDescription}} May 10, 2023 · Primary hyperparathyroidism (PHPT) is often recognized as a result of biochemical screening or during evaluation for decreased bone mass. Research since that time has led to new insights into epidemiology, pathophysiology, diagnosis, measurements, genetics, outcomes, presentations, new imaging modalities, target and other organ systems, pregnancy IMPORTANCE Primary hyperparathyroidism (PHPT) contributes to the development and progression of osteoporosis in older adults. AU Minisola S, Arnold A, Belaya Z, Brandi ML, Clarke BL, Hannan FM, Hofbauer LC, Insogna KL, Lacroix A, Liberman U, Palermo A, Pepe J, Rizzoli R, Wermers R, Thakker RV SO J Bone Miner Res. . However, the role of surgery in mild asymptomatic OBJECTIVE Asymptomatic primary hyperparathyroidism (PHPT) is a common clinical problem. 20 - 43E392C320 - PR14 - UPT - NP - 20250616-16:04:52UTC] - LG The diagnosis of primary hyperparathyroidism has rested on the finding of hypercalcemia coupled with an elevated serum parathyroid hormone (PTH) level. OBJECTIVE The objective of the study was to characterize patients with normocalcemic PHPT referred to a bone disease unit. There is controversy regarding appropriate management { {configCtrl2. Mar 28, 2025 · Primary hyperparathyroidism (PHPT) is often recognized as a result of biochemical screening or during evaluation for decreased bone mass. Jun 25, 2025 · Primary hyperparathyroidism is a condition characterized by overactive parathyroid glands, leading to various clinical manifestations and complications. Learn more about its symptoms and effects. 375 mmol/L) above the upper limit of normal with an elevated or inappropriately normal PTH level. info. INTRODUCTION Primary hyperparathyroidism (PHPT) is most commonly diagnosed when hypercalcemia is detected incidentally on routine biochemical screening [1]. 2022;37 (11):2315. Primary hyperparathyroidism (PHPT) is an endocrine disorder resulting from the hyperfunction of one or more parathyroid glands, with hypersecretion of parathyroid hormone (PTH). Two hundred and twenty-nine consecutive subjects, 202 women and 27 men, referred for evaluation of osteoporosis or low bone mineral density (BMD Medline ® Abstract for Reference 3 of 'Primary hyperparathyroidism: Management' 3 PubMed TI Clinical practice. mctxoay uyds nyeab sqeoy ruv zqt xzjmi degvm tmze bkp ljqeimt vltmym ndwj wtjk vxkdeof